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Vollenweider Csomor

Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Vollenweider Csomor

Completed research project

Title / Titel Role of dopamine and the DA-D2 receptor in sensory gating in healthy subjects with low PPI levels
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Prepulse inhibition (PPI) of the acoustic startle reflex provides a valuable translational model to study the neuropharmacological basis and treatment effect of antipsychotic medication on inhibitory or gating deficits in schizophrenia. Extensive animal studies suggest that glutamate, dopamine and serotonin within cortico-striato-thalamic-pontine pathways contribute to the modulation of PPI in schizophrenia. Although recent cross-sectional studies indicate that atypical and mixed 5-HT2/D2 antagonists such as clozapine may be superior over D2 antagonists (e.g. haloperidol) in normalizing PPI deficits in schizophrenia, no firm conclusion can yet be drawn. Moreover, recent studies suggest that PPI may reflect rather a trait than solely a state marker of information processing deficits in schizophrenia. In fact, relative low PPI levels are also found in clinically unaffected relatives of schizophrenia patients and to a certain proportion also in not otherwise defined healthy subjects. Therefore, healthy subjects with low PPI values may provide a unique model to test the relative contribution of different neurotransmitter systems to the modulation of PPI and to test the impact of novel antipsychotics on PPI. In this within-subject study, the hypothesis that the D2 antagonist haloperidol may improves prepulse inhibition in healthy subjects with low versus those with high PPI levels will be tested. In addition, cortical gating as indexed by p50 suppression using EEG-ERP technique will also be assessed. The relationship between preattentive (PPI) and cortical gating (p50) as well as attention, working memory, learning, and executive functioning shall be investigated using a set of the CANTAB neuropsychological test battery.
Publications / Publikationen Csomor P.A., Stadler R.R., Yee b., Feldon J., Geyer M., Vollenweider F.X. "Haloperidol differentially modulates prepulse inhibition and P50 suppression in healthy humans stratified for low and high gating levels", 2008 Feb;33(3):497-512.

Stadler R., "Effect of the D2 antagonist haloperidol on sensorimotor gating and cognition in healthy subjetcs.", Diploma Thesis. Psychiatric University Hospital Zurich & Behavioural Neurobiology Laboratory (ETH-ZH).

Keywords / Suchbegriffe sensory gating, acoustic startle reflex, PPI, p50 suppression, antipsychotics, EEG-ERP, human
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. med. Franz X. Vollenweider (Project Leader) vollen@bli.uzh.ch
Dipl. Natw. ETH Philipp Csomor (Project Leader) csomor@bli.uzh.ch
Reneé Stadler  
Funding source(s) /
Unterstützt durch
Foundation
Heffter Reserach Foundation USA
In collaboration with /
In Zusammenarbeit mit
Prof. J. Feldon, Laboratory of Behavioural Neurobiology, ETH Zurich Switzerland
Duration of Project / Projektdauer Sep 2005 to Mar 2008