Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Schuepbach

Completed research project

Title / Titel A prospective controlled study on the predictive role of clinical symptoms and functional transcranial Doppler sonography on the development of vocational function in schizophrenia
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Schizophrenia is a severe mental disorder with long-term disability. Negative symptoms and cognitive deficits such as executive functions play a crucial role in long-lasting vocational deficits, and the underlying pathophysiological mechanisms of those symptoms have been extensively investigated with neuroimaging studies. Despite these facts, to the best of our knowledge no studies have examined the associations between pathophysiological variables such as cerebral blood flow (CBF) under challenge of executive functions and work performance. The primary objective of this prospective controlled study is to examine the association between CBF during executive challenge as assessed by functional Transcranial Doppler sonography (fTCD) and vocational functioning in chronic schizophrenia and in a control group of patients suffering from depression. We hypothesize that fTCD can be used to predict work performance in schizophrenia on a routine basis.
Publications / Publikationen Schuepbach D., Hill S.K., Sanders R.D., Hell D., Keshavan M.S., Sweeney J.A. Early, Treatment-Induced Improvement of
Negative Symptoms Predicts Cognitive Functioning in Treatment-Naïve First-Episode Schizophrenia: a 2-Year Follow-Up. Schizophrenia Bulletin, 30 (4):837-848, 2004

Frauenfelder B.A., Schuepbach D., Baumgartner R.W., Hell D. Specific alterations of cerebral hemodynamics during a planning task: a transcranial Doppler sonography study. Neuroimage 22:1223-1230, 2004.

Sanders R.D., Schuepbach D., Goldstein G., Haas G.L., Sweeney J.A., Keshavan M.S. Relationships between cognitive and neurologic performance in neuroleptic-naive psychosis. Journal of Neuropsychiatry and Clinical Neurosciences 16 (4):480-487, 2004.

Keywords / Suchbegriffe depression, cbf, fTCD, neurological signs, schizophrenia, vocational functioning
Project leadership and contacts /
Projektleitung und Kontakte
Dr. Daniel Schuepbach (Project Leader)
Funding source(s) /
Unterstützt durch
In collaboration with /
In Zusammenarbeit mit
Prof. Dr. R.W. Baumgartner
Department of Neurology
University of Zurich
Prof. Dr. R.D. Sanders
Wright State University School of Medicine, Dayton, Ohio
and Department of Veterans Affairs, Dayton, Ohio
United States
Uta Jakobs
Psychiatric University Hospital Zurich
Duration of Project / Projektdauer Apr 2005 to Mar 2008