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Vollenweider Benz

Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Vollenweider Benz

Completed research project

Title / Titel Effects of d-amphetamine on sensorimotor gating, decision making and psychological measures. A double-blind placebo-controlled dose-effect study in man.
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Animal studies demonstrate that increased dopaminergic activity in limbic brain regions disrupts sensorimotor gating as indexed by prepulse inhibition (PPI) of the startle reflex. Gating deficits may render schizophrenia patients to attentional deficits and psychosis. However, whether increased dopamine activity results in PPI deficits in man, and how such PPI deficits are linked to cognitive abnormalities has not yet been established humans. The present study aims to further elucidate the effect of d-amphetamine, an indirect dopamine agonist, on PPI and cognitive performance in healthy human subjects (n=16). The plasticity of sensory gating will be assessed by measuring prepulse inhibition and habituation of the acoustic startle reflex. Cognitive performance (attention, memory, planning and strategy) will be assessed using neuropsychological tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), sequential behavior in decision making investigated using a computerized two-choice prediction task (Paulus et al, 2000). Subjective effects of psilocybin on mood states are assessed by use of the EWL-60 mood rating scale, and dose-dependent alterations in consciousness are rated via 5-D ASC questionnaires.
Publications / Publikationen Benz MA. 2005. "Untersuchung der Wirkung von d-Amphetamin auf die sensomotorische Informationsverarbeitung (PPI) und Aufmerksamkeit bei gesunden Probanden." Psychiatrische Universitätsklinik Zürich, Sektor Ost und Zentrale Spezialangebote, Prof. Dr. med. D. Hell, Zürich.

Paulus MP, Perry W, Braff DL (2000) The nonlinear, complex sequential organization of behavior in schizophrenic patients: neurocognitive strategies and clinical correlations. Biological Psychiatry 46: 662-670

Vollenweider FX, Geyer MA (2001): A systems model of altered consciousness: Integrating natural and drug-induced psychoses. Brain Res Bull 56: 495-507

Keywords / Suchbegriffe sensorimotor gating, cognition, decision making, dopamine, d-amphetamine
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. F.X. Vollenweider (Project Leader) vollen@bli.uzh.ch
Pract med. M. Benz (Project Leader) mbenz@bli.uzh.ch
Funding source(s) /
Unterstützt durch
Foundation
Heffter Research Institute (HRI), USA
In collaboration with /
In Zusammenarbeit mit
Prof. M. Geyer and Prof. M. Paulus, Department of Psychiatry, University of California, San Diego, United States
Duration of Project / Projektdauer Jan 2005 to Jun 2007