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Vollenweider Hasler

Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Vollenweider Hasler

Completed research project

Title / Titel Psychological, cardiovascular, neuroendocrine and autonomic effects of the 5-HT2A agonist psilocybin in man. A double-blind placebo-controlled dose-effect study.
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung The indolealkylamine psilocybin is the main psychoactive principle of hallucinogenic mushrooms such as Psilocybe cubensis and Psilocybe semilanceata. Its unique psychopharmacological properties capacitate psilocybin to serve as an experimental tool in neuroscience to study the neurobiological basis of altered states of consciousness. In order to better understand the neurophysiological, especially neuroendocrine mechanisms following 5-HT2 receptor stimulation in humans, 8 healthy subjects receive placebo and 4 doses of psilocybin (low - high dose) in random order. Dose-dependent effects of psilocybin on physiological functions are investigated systematically by measuring ECG, heart rate, blood pressure and body temperature, clinical-chemical blood parameters and hormones. Influence of psilocybin on sustained attention, mood states and core dimensions of altered states of consiousness are assessed by use of psychometric scales (FAIR, EWL-60, and 5-D ASC questionnaires). The study aims to better characterize the pharmacologic properties of psilocybin investigated preliminarily in two earlier clinical trials.
Publications / Publikationen Hasler F, Grimberg U, Benz MA, Huber T, Vollenweider FX (2004) Acute psychological and physiological effects of psilocybin in healthy humans. A double-blind placebo-controlled dose-effect study. Psychopharmacology 172:145-156
Keywords / Suchbegriffe Keywords: Psychology, neuroendocrinology, cardiovascular, serotonin, 5-HT2A, psilocybin
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. F.X. Vollenweider (Project Leader)  
Dr. F. Hasler (Project Leader) fehasler@bli.unzih.ch
Funding source(s) /
Unterstützt durch
Other Public Sources (e.g. Federal or Cantonal Agencies), Foundation
Heffter Research Institute (HRI), USA, BAG Switzerland
Duration of Project / Projektdauer Oct 2000 to May 2004