Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Vollenweider

Completed research project

Title / Titel Functional correlates of sensorimotor gating in healthy humans with low and high PPI using H215O-PET
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung The prepulse inhibition (PPI) of the acoustic startle reflex has been discussed to reflect an intermediate phenotype marker of sensorimotor gating in schizophrenia. Moreover, deficits in PPI were found to correlate with attentional deficits (Ludewig and Vollenweider, 2002) and thought disturbances in acute schizophrenia (Perry et al. 2000). Low PPI was also found in relatives of schizophrenia patients without manifestation of the illness. Moreover, we recently found that about 25% of healthy controls also exhibit low PPI (<30%). Whether healthy subjects with low PPI exhibit cognitive impairments or aberrant brain activation patterns compared to subjects with normal or high PPI is completely unknown.

The aim of the present study is to investigate whether normal subjects with low PPI (<30%) show aberrant brain activation patterns during PPI compared to normal subjects with high PPI (>70%) using [H215O]PET. A second is to further investigate the relationship between PPI and cognitive performance (attention, working memory, and executive functions) in normal subjects using the CANATAB test battery.
Publications / Publikationen Ludewig K, Ludewig S, Seitz A, Martina Obrist M, Geyer MA, Vollenweider FX (2002) The acoustic startle reflex and its modulation: Effects of age and gender in humans. Biol Psychology (in press)

Ludewig K, Ludewig S, Geyer MA, Vollenweider FX (2002) Sensory gating and attention in first-episode schizophrenia. 11th Biennal Winter Workshop on Schizophrenia, Davos, Februar 24 - March 1, 20, Schizophrenia Research, 216-217.

Keywords / Suchbegriffe functional brain imaging, schizophrenia research, sensorimotor gating, Key words: sensorimotor gating, prepulse inhibition (PPI), positron emission tomography (PET), cognition, healthy humans
Project leadership and contacts /
Projektleitung und Kontakte
PD Dr. F.X. Vollenweider (Project Leader)
Dipl. Natw. ETH Ph. Csomor
Funding source(s) /
Unterstützt durch
NARSAD (USA) , EMDO Stiftung, Hartmann-Müller Stiftung
In collaboration with /
In Zusammenarbeit mit
Prof. J. Feldon, Institute for Toxicology ETH Zurich Switzerland
Prof. K. von Schulthess and Prof. Prof. A. Buck, Department of Nuclear Medicine, University Hospital, Zürich Switzerland
Duration of Project / Projektdauer Oct 2002 to Jul 2005