Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Schuepbach

Completed research project

Title / Titel Cerebral hemodynamics under prefrontal activation: an emphasis on short-term changes of cerebral blood flow in schizophrenia
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Transcranial Doppler sonography (TCD) assesses relative cerebral blood flow (CBF) during prefrontal function, and the excellent resolution in time of this technique may be used to investigate short-term CBF changes. Patients with schizophrenia yield decreased frontal CBF during executive functions, and we have recently shown that TCD specifically detects those alterations. However, there are virtually no studies that systematically investigate short-term CBF changes during prefrontal challenge in this patient group. Patients with schizophrenia and age- and gender matched healthy subjects are investigated. Measurements: Mean cerebral blood flow velocity (CBFV) in both middle and anterior cerebral arteries, while subjects perform the Wisconsin Card Sorting Test and the Tower of London. Examining short-term CBF changes under prefrontal activation harbours several important implications: the association of defined cognitive processes with cerebral hemodynamics of defined length, the degree of differently decreased cerebral blood flow in patients with schizophrenia during those time periods, and its link to clinical symptomatology, increased insight into the pathophysiology of normal cerebral metabolism and that of patients with schizophrenia. Further, there is a great potential to stimulate future research, like correlational studies with anatomical findings in schizophrenia or functional findings of smaller brain areas. This project has been carried out with collaboration of the Department of Neurology, University of Zurich.
Publications / Publikationen Schuepbach D, Merlo MCG, Dierks T, Brenner HD (2002) Cerebral Hemodynamic Response Induced by the Tower of Hanoi Puzzle and the Wisconsin Card Sorting Test. Neuropsychologia 40, 39-53

Schuepbach D, Goenner F, Staikov I, Mattle H, Hell D, Brenner HD (2002) Temporal modulation of cerebral hemodynamics under prefrontal challenge in schizophrenia: a transcranial Doppler sonography study. Psychiatry Research: NeuroImaging 115, 155-170

Frauenfelder BA, Schuepbach D, Baumgartner RW, Hell D (2004). Specific alterations of cerebral hemodynamics during a planning task: a transcranial Doppler sonography study. Neuroimage 22,1223-1230.

Keywords / Suchbegriffe Cerebral blood flow, executive function, neuropsychology, prefrontal cortex, Transcranial Doppler sonography
Project leadership and contacts /
Projektleitung und Kontakte
Dr. med. D. Schuepbach (Project Leader)
Funding source(s) /
Unterstützt durch
Hartmann Müller-Stiftung für Medizinische Forschung
In collaboration with /
In Zusammenarbeit mit
Prof. Dr. med. R. Baumgartner
Department of Neurology, University of Zurich
Duration of Project / Projektdauer Jul 2002 to May 2005