Kochi Pascual-Marqui

Fakultäten » Medizinische Fakultät » Psychiatrische Universitätsklinik » Psychiatrie, Psychotherapie und Psychosomatik, Klinik für » Prof. Dr. Daniel Hell (emeritiert) » Kochi Pascual-Marqui

Completed research project

Title / Titel Electric Brain Wave Imaging: a new technique for functional mapping of the human brain.
PDF Abstract (PDF, 14 KB)
Summary / Zusammenfassung Electric Brain Wave Imaging is a new functional tomography that computes, from high time-resolution electroencephalographic measurements (EEG), the time varying 3D spatial distribution of electric neuronal activity. The current density (electric neuronal activity) is estimated under the assumption that it satisfies a wave equation. Wave equations for the cortical electric potential have been derived based on well-known neurophysiological data, and have been experimentally validated elsewhere. However, up to the present, this model has not been applied to determine electric neuronal activity. The goals of this project are: (1) To develop and implement the method in the form of computer programs. (2) To fully evaluate its spatio-temporal localization properties. (3) To apply the method in the comparison of control subjects and pathological subjects (depressed and schizophrenic patients), based on spontaneous EEG recordings. Electric Brain Wave Imaging allows the computation of time varying 3D images of the following types: (1) afferent activity, (2) cortical activity in response to afferent activity, and (3) intrinsic cortical activity independent of afferent activity. Furthermore, the method also allows the estimation of two important global brain parameters: (1) the velocity of spatial transmission of activity in the cortex, and (2) the existence (if any) of the characteristic oscillation frequency of the cortex. Preliminary analyses of an epoch of EEG (2 seconds) recorded from a single subject show that the alpha rhythm is not due to an intrinsic oscillation of the cortex, but rather that it is being forced (afferent activity) to oscillate. The estimated velocity of propagation of alpha cortical activity was 26 cm/sec, which is very close to values measured in animal experiments [6]. In addition, maximum afferent activity and maximum cortical activity (forced by afferent activity) are located in posterior brain regions, whereas intrinsic cortical activity independent of afferent activity is multi-focal widely distributed throughout the cortex.
Publications / Publikationen Pascual-Marqui, R.D., Michel, C.M., and Lehmann, D. (1994) Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. International Journal of Psychophysiology, 18:49-65.
Keywords / Suchbegriffe Neuroimaging, EEG, LORETA
Project leadership and contacts /
Projektleitung und Kontakte
Kieko Kochi (Project Leader)
R.D. Pascual-Marqui (Project Leader)
Evangelos Matsinos
Dietrich Lehmann
Funding source(s) /
Unterstützt durch
Stiftung KEY Institute
Duration of Project / Projektdauer Jan 1999 to Dec 2001